Referenzen

In den folgenden Publikationen habe ich als Co-Author mitgewirkt und war an der Gestaltung der zugehörigen Abbildungen ganz oder zumindest teilweise beteiligt.

Hinweis: Bei den Journalen mit Open Access habe ich die Abbildungen als Link gesetzt, so daß diese direkt aufgerufen werden können.

•  Schramm A, Köster J, Assenov Y, Althoff K, Peifer M, Mahlow E, Odersky A, Beisser D, Ernst C, Henssen AG, Stephan H, Schröder C, Heukamp L, Engesser A, Kahlert Y, Theissen J, Hero B, Roels F, Altmüller J, Nürnberg P, Astrahantseff K, Gloeckner C, De Preter K, Plass C, Lee S, Lode HN, Henrich KO, Gartlgruber M, Speleman F, Schmezer P, Westermann F, Rahmann S, Fischer M, Eggert A, Schulte JH (2015): Mutational dynamics between primary and relapse neuroblastomas. Nature Genetics 47(8):872-7.

• Schwermer M, Lee S, Köster J, van Maerken T, Stephan H, Eggert A, Morik K, Schulte JH, Schramm A (2015): Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors. Oncotarget 6(17):15425-35. Figure 1 - Figure 2 - Figure 3 - Figure 4 - Figure 5 - Figure 6 - Supplementary Figures and Table

• Pajtler KW, Mahlow E, Odersky A, Lindner S, Stephan H, Bendix I, Eggert A, Schramm A, Schulte JH (2014): Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells. Oncotarget 5(22):11180-92. Figure 1 - Figure 2 - Figure 3 - Figure 4 - Figure 5 - Supplementary Figures
  

•  Thor T, Künkele A, Pajtler KW, Wefers AK, Stephan H, Mestdagh P, Heukamp L, Hartmann W, Vandesompele J, Sadowski N, Becker L, Garrett L, Hölter SM, Horsch M, Calzada-Wack J, Klein-Rodewald T, Racz I, Zimmer A, Beckers J, Neff F, Klopstock T, De Antonellis P, Zollo M, Wurst W, Fuchs H, Gailus-Durner V, Schüller U, Hraběde Angelis M, Eggert A, Schramm A, Schulte JH. (2014): MiR-34a deficiency accelerates medulloblastoma formation in vivo. International Journal of Cancer 136(10):2293-303. Figure 1 - Figure 2 - Figure 3
  

• Schulte HJ, S. Schulte, L. C. Heukamp, H. Stephan, M. Fischer, A. Schramm, A. Eggert (2013):Targeted Therapy for Neuroblastoma: ALK Inhibitors. Klinische Pädiatrie 2013 Nov;225(6):303-308.

• Menke, K., M. Bornschein, H. Stephan, K. W. Pajtler, J. Eisenbraun, A. Schramm, T. J. Zuzak (2013): Viscum album inhibits cell growth, migration and invasion of pediatric tumor cell lines – But effects are limited at concentrations found in serum. In: R. Scheer, S. Alban, H. Becker, W. Blaschek, F. H. Kemper, W. Kreis, H. Matthes, H. Schilcher, R. Stange (Hrsg.): Die Mistel in der Tumortherapie 3 – Aktueller Stand der Forschung und klinische Anwendung. ISBN 978-3-86864-032-8. KVC-Verlag Essen.

• Zuzak, T.J., M. Bornschein, K. Menke, H. Stephan, K. Pajtler, J. Eisenbraun, A. Schramm (2011):Viscum album inhibits cell growth, migration and invasion of pediatric tumor cell lines – But effects are limited at concentrations found in serum. Phytomedicine 01/2011; 18.

• Gustmann, S., L. Klein-Hitpass, H. Stephan, S. Weber, N. Bornfeld, M. Kaulisch, D. R. Lohmann, N. Dünker (2011): Loss at chromosome arm 16q in retinoblastoma: confirmation of the association with diffuse vitreous seeding and refinement of the recurrently deleted region. Genes, Chromosomes & Cancer 50(5): 327-337.

• Stephan, H., R. Boeloeni, A. Eggert, N. Bornfeld, A. Schueler (2008): Photodynamic therapy in retinoblastoma: effects of verteporfin on retinoblastoma cell lines. Investigative Ophthalmology & Visual Science 49(7): 3158-3163. Figure 1 - Figure 2 - Figure 3 - Figure 4 - Figure 5 - Figure 6 - Figure 7 - Figure 8 - Figure 9
  

• Stephan, H., J. L. Zakrzewski, R. Boloni, C. Grasemann, D. R. Lohmann, A. Eggert (2008): Neurotrophin receptor expression in human primary retinoblastomas and retinoblastoma cell lines. Pediatric Blood & Cancer 50(2): 218-222.

• Gratias, S., A. Schuler, L. K. Hitpass, H. Stephan, H. Rieder, S. Schneider, B. Horsthemke, D. R. Lohmann (2005): Genomic gains on chromosome 1q in retinoblastoma: consequences on gene expression and association with clinical manifestation. International Journal of Cancer 116(4): 555-563.

• Grasemann, C., S. Gratias, H. Stephan, A. Schuler, A. Schramm, L. Klein-Hitpass, H. Rieder, S. Schneider, F. Kappes, A. Eggert, D. R. Lohmann (2005): Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma. Oncogene 24(42): 6441-6449.

• Ballweber, E., E. Hannappel, T. Huff, H. Stephan, M. Haener, N. Taschner, D. Stoffler, U. Aebi, H. G. Mannherz (2002): Polymerisation of chemically cross-linked actin:thymosin beta(4) complex to filamentous actin: alteration in helical parameters and visualisation of thymosin beta(4) binding on F-actin. Journal of Molecular Biology 315(4): 613-625.

• Napirei, M., H. Karsunky, B. Zevnik, H. Stephan, H. G. Mannherz, T. Moroy (2000): Features of systemic lupus erythematosus in Dnase1-deficient mice. Nature Genetics 25(2): 177-181.

• Stephan, H, B. Polzar, H. G. Mannherz (2000): Sein oder nicht sein? - Der Programmierte Zelltod. Naturwissenschaftliche Rundschau 53: 273-281.

• von Kobyletzki, G., O. Heine, H. Stephan, C. Pieck, M. Stucker, K. Hoffmann, P. Altmeyer, H. G. Mannherz (2000): UVA1 irradiation induces deoxyribonuclease dependent apoptosis in cutaneous T-cell lymphoma in vivo. Photodermatology, Photoimmunology & Photomedicine 16(6): 271-277.

• Rauen, U., B. Polzar, H. Stephan, H. G. Mannherz, H. de Groot (1999): Cold-induced apoptosis in cultured hepatocytes and liver endothelial cells: mediation by reactive oxygen species. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 13(1): 155-168.

• Stephan H, H. G. Mannherz (1998): Der Programmierte Zelltod - Harakiri mit tausend Schnitten. RUBIN Wissenschaftsmagazin 4/2000.

• Rauch, F., B. Polzar, H. Stephan, S. Zanotti, R. Paddenberg, H. G. Mannherz (1997): Androgen ablation leads to an upregulation and intranuclear accumulation of deoxyribonuclease I in rat prostate epithelial cells paralleling their apoptotic elimination. Journal of Cell Biology 137(4): 909-923.

• Stephan, H., B. Polzar, F. Rauch, S. Zanotti, C. Ulke, H. G. Mannherz (1996): Distribution of deoxyribonuclease I (DNase I) and p53 in rat testis and their correlation with apoptosis. Histochemistry and Cell Biology 106(4): 383-393.

• Zanotti, S., B. Polzar, H. Stephan, U. Doll, J. Niessing, H. G. Mannherz (1995): Localization of deoxyribonuclease I gene transcripts and protein in rat tissues and its correlation with apoptotic cell elimination. Histochemistry and Cell Biology 103(5): 369-377.

• Polzar, B., S. Zanotti, H. Stephan, F. Rauch, M. C. Peitsch, M. Irmler, J. Tschopp, H. G. Mannherz (1994): Distribution of deoxyribonuclease I in rat tissues and its correlation to cellular turnover and apoptosis (programmed cell death). European Journal of Cell Biology 64(1): 200-210.

• Peitsch, M. C., B. Polzar, H. Stephan, T. Crompton, H. R. MacDonald, H. G. Mannherz, J. Tschopp (1993): Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). EMBO Journal 12(1): 371-377.
  

Im Rahmen meiner Tätigkeit als wissenschaftlicher Angestellter des Universitätsklinikums Essen habe ich die Abbildungen in den folgenden Veröffentlichungen, in denen ich nicht selbst als Co-Author geführt bin, vollständig oder zumindest teilweise gestaltet.

• Künkele A, Jurklies C, Wieland R, Lohmann D, Bornfeld N, Eggert A, Schulte JH.: Chemoreduction improves eye retention in patients with retinoblastoma: a report from the German Retinoblastoma Reference Centre. British Journal of Ophthalmology 2013 Oct;97(10):1277-83.

• Pajtler KW, Rebmann V, Lindemann M, Schulte JH, Schulte S, Stauder M, Leuschner I, Schmid KW, Köhl U, Schramm A, Eggert A.: Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma cells. International Journal of Cancer 2013 Aug 15;133(4):908-19. Figure 1 - Figure 2 - Figure 3 - Figure 4 - Figure 5 -
  

• Pajtler KW, Weingarten C, Thor T, Künkele A, Heukamp LC, Büttner R, Suzuki T, Miyata N, Grotzer M, Rieb A, Sprüssel A, Eggert A, Schramm A, Schulte JH.: The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma. Acta Neuropathologica Communications 2013 May 29;1:19. Figure 1 - Figure 2 - Figure 3 - Figure 4
  

• Schramm A, Köster J, Marschall T, Martin M, Schwermer M, Fielitz K, Büchel G, Barann M, Esser D, Rosenstiel P, Rahmann S, Eggert A, Schulte JH.: Next-generation RNA sequencing reveals differential expression of MYCN target genes and suggests the mTOR pathway as a promising therapy target in MYCN-amplified neuroblastoma. International Journal of Cancer 2013 Feb 1;132(3). Figure 1 - Figure 2 - Figure 3 - Figure 4 - Figure 5 - SupplFigure 1 - SupplFigure 2
  

• Schramm A, Schowe B, Fielitz K, Heilmann M, Martin M, Marschall T, Köster J, Vandesompele J, Vermeulen J, de Preter K, Koster J, Versteeg R, Noguera R, Speleman F, Rahmann S, Eggert A, Morik K, Schulte JH.: Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome. British Journal of Cancer 2012 Oct 9;107(8):1409-17. Figure 1 - Figure 2- Figure 3 - Figure 4 - SupplFigure 1
  

• Sprüssel A, Schulte JH, Weber S, Necke M, Händschke K, Thor T, Pajtler KW, Schramm A, König K, Diehl L, Mestdagh P, Vandesompele J, Speleman F, Jastrow H, Heukamp LC, Schüle R, Dührsen U, Buettner R, Eggert A, Göthert JR.: Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation. Leukemia 2012 Sep;26(9):2039-51

• Künkele A, De Preter K, Heukamp L, Thor T, Pajtler KW, Hartmann W, Mittelbronn M, Grotzer MA, Deubzer HE, Speleman F, Schramm A, Eggert A, Schulte JH.: Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas. Neuro Oncology 2012 Jul;14(7):859-69. Figure 1 - Figure 2 - Figure 3 - Figure 4 - SupplFigure 1 - SupplFigure 2
  

• Heukamp LC, Thor T, Schramm A, De Preter K, Kumps C, De Wilde B, Odersky A, Peifer M, Lindner S, Spruessel A, Pattyn F, Mestdagh P, Menten B, Kuhfittig-Kulle S, Künkele A, König K, Meder L, Chatterjee S, Ullrich RT, Schulte S, Vandesompele J, Speleman F, Büttner R, Eggert A, Schulte JH.: Targeted expression of mutated ALK induces neuroblastoma in transgenic mice. Science Translational Medicine 2012 Jul 4;4(141):141ra91.

• Schulte JH, Göthert JR.: Maßgeschneiderte Nager: Genetisch veränderte Mäuse helfen bei der Entwicklung zielgerichteter Therapien. UNIKATE 42/2012